SREBF1 and hepatocellular carcinoma: Furthermore, suppression of the adenosine triphosphate citrate lyase, acetyl-CoA carboxylase, fatty acid synthase, stearoyl-CoA desaturase 1, or sterol regulatory element-binding protein 1, which are involved in lipogenesis, reduced proliferation, and survival of HCC cell lines, and AKT-dependent cell proliferation [67].