In HCC cell lines, the Warburg effect is elevated with increasing glucose uptake, and it is revealed that miR-873 activates the key glycolytic proteins AKT/mTOR via targeting Nedd4 family-interacting protein 1 (NDFIP1), which initiates metabolic change and causes hepatocellular carcinoma formation and metastasis [43]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.