Studies conducted by Broekgaarden et al. [96] co-encapsulated acriflavine (ACF) (a HIF-1 inhibitor) in zinc phthalocyanine (ZnPC) functionalized with endothelium-targeting liposomes (ZnPC-ETLs) to inhibit HIF-1 and increase PDT efficacy in cancer cells. This evidence concerns the gene HIF1A and cancer.