Examples include: CLCA4 (chloride channel accessory 4), which codes for the calcium-activated chloride channel family and is involved in colorectal cancer [23], and SLC26A3 (solute carrier family 26 member 3), a transporter for chloride/bicarbonate exchange and the maintenance of intestinal epithelial barrier integrity [24]. The gene discussed is ANO1; the disease is colorectal cancer.