In general, indole derivatives have been reported to exert marked anti-NSCLC action through diverse mechanisms including the induction of apoptosis, the inhibition of crucial biological targets such as microtubule, topoisomerases, protein kinases (e.g., Akt), and histone deacetylases (HDACs) [58,59,60,61,62]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.