FAS and non-small cell lung carcinoma: Bak et al. indicated that 5-hydroxy-7,4′-diacetyloxyflavanone-N-phenyl hydrazone (N101-43) induced apoptosis via the up-regulation of Fas/FasL expression, the activation of caspase cascade, and the inhibition of the PI3K/Akt signaling pathway in NSCLC cells [36].