In addition, NC009-1 activates apolipoprotein E (APOE) and neurotrophic receptor tyrosine kinase 1 (NTRK1) in amyloid beta (Aβ)-GFP SH-SY5Y cells, and Aβ precursor protein (APP)Swe/presenilin 1 (PS1)M146V/microtubule associated protein tau (Tau)P301L triple transgenic Alzheimer’s disease (AD) mouse models [14], and decreases IL-1β-mediated pathway in SCA type 3 SH-SY5Y cell model inflamed with IFN-γ-primed HMC3 conditioned medium [15]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.