Previously, indole compound NC009-1 (C19H16N2O3) has been shown to have aggregation-reducing and neuroprotective effects by activating heat shock protein beta 1 (HSPB1) in tauopathy cell model [12] and spinal spinocerebellar ataxia (SCA) type 17 cell and mouse models [13]. This evidence concerns the gene HSPB1 and tauopathy.