In addition, neonatal exposure to the CAR activator TC and the pregnane X receptor (PXR) activator pregnenolone 16alpha-carbonitrile (PCN) would result in a reduction of the peroxisome proliferator-activated receptor alpha (PPARα) signaling pathway in the adult liver, indicating that neonatal exposure to several xenobiotics might induce certain idiosyncratic lipid metabolism disorders in adulthood [43]. The gene discussed is NR1I2; the disease is Disorder of lipid metabolism.