Paris polyphylla derivative polyphyllin D induces ER stress and cell death via GRP78, CHOP, and caspase-3 cleavage in NSCLC cells NCI-H460, and Saussurea lappa and Auckland lappa derivative dehydrocostuslactone mediates ER stress and cell death by activating PERK-CHOP and IRE-1-JNK signaling and inducing ROS and Ca2+ release in NSCLC cells A549 and NCI-H460 [7,8]. The gene discussed is EIF2AK3; the disease is non-small cell lung carcinoma.