EMT marker Twist knockdown induces caspase-3- and -7-dependent apoptotic cell death by inhibiting the phosphorylation of EGFR, Akt, vimentin, and Twist1, and by activating E-cadherin in EGFR-TKI gefitinib and AZD9291-treated gefitinib-resistant lung cancer cells [55]. The gene discussed is VIM; the disease is lung cancer.