On the other hand, it is noticeable that in the literature, depletion of UPF1 or SMG5 or SMG7 has been associated with increased susceptibility to infection by positive-strand RNA viruses [39] and that, accordingly, in our experimental setting, downregulation of SMG5 and SMG7 occurred concomitantly with an exponential increase of viral genes. Here, SMG5 is linked to infection.