miR-451a directly targets and regulates many proteins, such as the YWHAZ/14-3-3ζ protein, which is associated with the suppression of type I IFN, IL-6, TNF-α, and RANTES expression, and CXCL16, which is the chemokine responsible for the recruitment of monocytes and tumor-associated macrophage differentiation [55,56,57]. This evidence concerns the gene CCL5 and neoplasm.