Decreasing Bacteroidetes bacteria in the gut causes dysbiosis and induces a thinner mucin layer and weakened cellular adhesion in the gut, leading to leaky gut syndrome; these effects can, in turn, lead to obesity, hypertension, diabetes, dyslipidemia, arteriosclerosis, NASH, and lifestyle-related diseases [154]. The gene discussed is MUC5AC; the disease is Hypertension.