PTEN and breast cancer: CMT in dogs share similarities with breast cancer (BC) in humans: In dogs, diverse genes including Tumor protein 53 (p53), Breast Cancer1 (BRCA1), Breast Cancer 2 (BRCA2), Phosphatase and Tensin Homolog (PTEN), as well as E-cadherin and Serine/Threonine kinase11 (STK11) are known contributors of CMT [13], which have also been attributed to human BC.