CD274 and neoplasm: These proteins include PD-L1, which is related to the immunosuppressive capacity of tumor cells; VEGFR-2 (vascular endothelial growth factor receptor), which plays a key role in the formation and growth of new tumor blood vessels; and c-Myc protein, which intervenes in numerous processes that are altered in tumor cells, such as cell cycle, angiogenesis, or overexpression of oncoproteins [20].