The improved overall and disease-free survival of cutaneous melanoma patients with elevated CD47 mRNA expression in their tumors [22] is consistent with these data and supports a protective role for CD47 in the melanoma tumor microenvironment that is inconsistent with the prevailing hypothesis that CD47 functions primarily on cancer cells to shield them from clearance by innate immune cells [34,35]. The gene discussed is CD47; the disease is neoplasm.