Here, we identified a splice variant of MYCN that is induced in activated CD8 T cells, which is inhibited by TSP1 in a CD47-dependent manner, and found that MYCN expression positively correlates with multiple markers of CD8 T cells and their activation, including CD8A, CD8B, TNF, TIGIT, CD40LG, IL7R, PDCD1 (PD-1), SELL (CD62L), ENTPD1 (CD39), MCL1, and CD47 in cutaneous melanomas. This evidence concerns the gene TIGIT and cutaneous melanoma.