Antisense knockdown of CD47 can delay the growth of some cancers in immune-competent mice, but tumor ablation and increased long-term survival have been achieved only by combining with local tumor irradiation, cytotoxic chemotherapy, or anti-CTLA4 or anti-PD-1 ICI [8,9,10,11,12]. The gene discussed is PDCD1; the disease is neoplasm.