HSPB1 and cancer: Specifically, OGX-427 (Apatorsen, OncoGenex, Vancouver, BC, Canada), a sequence of second-generation antisense oligonucleotides (ASO) generated using a 2′-O-(2-methoxy) ethyl (2′-MOE) backbone, which targets HSPB1 mRNA, is reported to enhance chemosensitivity of cancer cells to therapeutic agents; to exert anti-proliferative effects and to also inhibit tumor growth in mice [20,21].