Taking into account available literature data, it is feasible that Tumor Necrosis Factor Receptor Superfamily Member 11b (TNFRSF11B), also called Osteoprotegerin (OPG), Chitinase 3-like protein-1 (YKL-40), and Cardiotrophin-1 (CT-1) could become candidates for potential biomarkers of OSA. The gene discussed is TNFRSF11B; the disease is obstructive sleep apnea syndrome.