De Luca Canto et al. found that several individual OSA serum and plasma biomarkers, such as combined kallikrein-1, uromodulin, urocortin-3, and orosomucoid-1 in children and IL-6 and IL-10 plasma concentrations in adults, have adequate diagnostic utility for identifying or excluding the presence of OSA [12]. This evidence concerns the gene UMOD and obstructive sleep apnea syndrome.