The top fifteen pathways identified by KEGG pathway analysis are as follows: hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, asthma, intestinal immune network for IgA production, T-cell receptor signaling pathway, leishmaniasis, inflammatory bowel disease, PD-L1 expression and PD-1 checkpoint pathway in cancer, antigen processing and presentation, allograft rejection, primary immunodeficiency, cell adhesion molecules, graft-versus-host disease, and viral myocarditis (Figure 3B). The gene discussed is CD274; the disease is inborn error of immunity.