Also related to the AKT/mTOR axis, Zeng et al. demonstrated that the overexpression of circRNA angiomotin like 1 (circAmotl1) protects against cardiomyopathy by binding to 3-phosphoinositide-dependent kinase 1 (PDK1) and AKT1 in vivo [114]. The gene discussed is AKT1; the disease is cardiomyopathy.