Association with obesity and MetSThe minor allele G of rs4580704 showed lower risk of hypertension and diabetes.Protective effect the minor allele G of rs4580704 on insulin sensitivity when MUFA intake was >13.2% of energy.Different effects across CLOCK 3111T→C genotypes for saturated fatty acid intake (% of energy) (p = 0.017). The gene discussed is CLOCK; the disease is obesity due to melanocortin 4 receptor deficiency.