On the basis of this rationale in an interorgan approach to the physiology of CS, we formulated the hypothesis that Oxt may contract all the slow-twitch muscles as Oxt contracts the uterus, having a tonic, thermogenic, and analgesic effect [3], and that the metabolic syndrome of Oxt/Oxtr−/− mice was caused by muscular failure and depotentiation rather than increased food consumption. Here, OXTR is linked to metabolic syndrome.