The signaling pathways activated by VEGF play an irreplaceable role in the entire process of angiogenesis, from the increase in vascular permeability, basement membrane breakdown, endothelial cell proliferation, and differentiation to final tube formation, and play an important pathophysiological role in angiogenesis, embryonic development, wound healing, collateral circulation, inflammatory response, and tumor development [53,54,55]. Here, VEGFA is linked to neoplasm.