EPCAM and malignant colon neoplasm: Some pre-clinical experiments targeting EpCAM+ CSCs have been performed, i.e., Zhou et al. assessed EpCAM-targeting CAR-T cells and their killing efficiency in vitro by co-culture with colon cancer cell lines and demonstrated that EpCAM-CAR-T cells exhibited a significantly higher apoptotic effect on cancer cells compared with non-EpCAM-modified T cells [95].