Krebs et al. and Liu et al. demonstrated that Zeb1 expression strongly stimulates stemness, tumorigenicity, and tumor cell plasticity in pancreatic cancer; moreover, the epithelial-differentiated pancreatic cancer cells had a higher tumorigenic capacity when compared with mesenchymal-undifferentiated cells, in agreement with the view that EMT-MET dynamic transition reflects the stemness plasticity [70,71]. Here, ZEB1 is linked to familial pancreatic carcinoma.