CASP3 and neoplasm: AFP has a stimulating effect on the regulation of the cell cycle of the liver tumor [21], the suspension of its synthesis stops the cell cycle by delaying the transition from G1 to S. Silencing the AFP gene allows the synthesis of TNF-beta and the mutated p53 protein in HepG2 cells to be reduced, which prevents the apoptosis of tumor cells via the p53/Bax/caspase 3 pathway [6].