Genome sequencing studies have identified over 10,000 coding mutations of GRIN genes in various types of cancer, with a large proportion of these variants being found in GRIN2A and GRIN2B (COSMIC, the Catalogue Of Somatic Mutations In Cancer, accessed on 20 January 2023, https://cancer.sanger.ac.uk). The gene discussed is GRIN2B; the disease is cancer.