From the ECM-receptor interaction pathway analysis, it can be concluded that the decrease in the levels of ECM proteins, i.e., HSPG2, COL6A1, COL6A3, SPP1, THBS1, TNC, DAG1, FN1, COMP, GP6, VTN, SDC1, and CD44, may cause disturbances in the interactions of cells with the ECM and play an important role in the development and progression of cervical cancer. This evidence concerns the gene HSPG2 and cervical carcinoma.