AR and posterior cortical atrophy: The lead compound, T60 (PubChem CID: 36589274) 13, was reported as a potent inhibitor of both TopoIIα and TopoIIβ enzymatic activities, as well as having dual inhibitory activity on the androgen receptor (AR) (an oncogenic transcriptional factor that requires TopoIIβ) and AR-positive PCa cell growth [46].