AR and posterior cortical atrophy: On prostate cancer (PCa)-targeted TopoII inhibition, Jeon et al. [44] investigated the mechanism by which AK-I-190 [2-(3-trifluorophenyl)-4-(3-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-6-ol] inhibited TopoII by using various types of biological and spectroscopic evaluations, and they found that its inhibitory activity was through intercalating into DNA without stabilizing the DNA–enzyme cleavage complex, which resulted in significantly less DNA toxicity than etoposide and inhibited the growth of AR-negative PCa cells.