We reported that IRAK2 transcription is upregulated in BCSCs when an ER-stress inducer stimulates them, revealing an IRAK2 requirement in the presence of ER-stress; interestingly, IRAK2 upregulation in the presence of ER-stress agents was previously reported in a primary prostatic carcinoma cell line [12]. Here, IRAK2 is linked to prostate carcinoma.