In addition to metabolites, serum proteins have currently been used as cancer biomarkers, such as carcinoembryonic antigen (CEA), cytokeratin 19fragment (CYFRA 21-1), cancer antigen 125 (CA 125), neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCCA) [112,113]. The gene discussed is ENO2; the disease is cancer.