ACTB and Menkes disease: In another study using proteomics to analyze the plasma from 15 MD patients and 12 healthy controls, upregulated complement factor-B and H, fibrinogen α-chain, β-actin, pigment epithelium-derived factor and fibrinogen γ-chain were found in MD, while vitamin D-binding protein, apolipoprotein A-1 and β-2-glycoprotein were downregulated compared to the control group [129].