PDCD1 and neoplasm: In this study, we characterized the 13C-metabolic profile in response to the PD1 blockade in YUMMER1.7 syngeneic melanoma xenografts characterized for BrafV600E/wt Pten−/−Cdkn2−/−somatic mutations [37], allowing for the use of immunocompetent mice to fully integrate all aspects of the tumor microenvironment.