KLF4 and diabetes mellitus: To determine whether this applies to our CMECs and whether the observed dysregulation of KLF expression in diabetes is linked to the observed MEF2D dysregulation in our diabetic models, we knocked down MEF2A or MEF2D in nondiabetic HCMECs (Supplementary Figure S3A,B) and analyzed KLF2 and KLF4 gene expression.