NLRP3 KO mice have reduced motor dysfunction, striatal dopaminergic neuron death, microglial recruitment, IL-1β production, and caspase-1 activation when treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a compound widely used to induce PD in murine models [115,116]. The gene discussed is NLRP3; the disease is Parkinson disease.