McCracken et al. (2022) revealed the overexpression of HIF-1α/HIF-2α in the placental syncytiotrophoblast layer in both PE and severe IUGR, as a result of impaired binding of HIF-1α to a protein involved in its degradation process (von Hippel–Lindau protein) in IUGR placenta, and even more so in PE [56]. This evidence concerns the gene EPAS1 and fetal growth restriction.