An NEC-like cell in vitro model showed that SIRT1 overexpression inhibits LPS-induced cell apoptosis and suppresses high expression of proinflammatory factors (IL-6, IL-8 and TNF-α) and decreased expression of tight junction proteins (ZO-1, ZO-2 and claudin-4). The gene discussed is SIRT1; the disease is necrotizing enterocolitis.