CRTC2 and Iron deficiency anemia: Taking altogether these results we conclude that the activity of the sphingolipid pathway leaded by TORC2 and YPK1 to induce the synthesis of long-chain sphingolipids, is the main signal converging in Aft1 and induces its nuclear translocation to activate the iron regulon in order to maintain iron homeostasis in response to iron deficiency.