For example, geniposide was reported to significantly inhibit the expression of toll-like receptor (TLR)-4 and phosphorylation of NF-κB p65, p38 MAPK, JNK, and ERK in macrophages, paralleling with an attenuated systemic inflammation as shown by lower serum levels of TNF-α, IL-6 and IL-8 in HFD-fed apolipoprotein E (ApoE)−/− mice, which suppressed the development of atherosclerosis [68,113,114]. Here, APOE is linked to atherosclerosis.