RTN4 and Familial prostate cancer: In previous studies, the overexpression of RTN4 in prostate cancer cells was shown to block the cell cycle in the G2/M phase and to induce cell senescence [41] and the expression of inflammatory cytokines, such as CHOP, IL-6, and tumor necrosis factor (TNF)-α, in a muscle cell line (C2C12) [42].