TP53 and hepatocellular carcinoma: Chaudhary and colleagues [56], with deep learning based epidemiological modeling, reported that the aggressive subtype of HCC is associated more frequently with mutations of TP53, higher expression of KRT19 and EPCA and tumor marker of BIRC5 with activated WNT-CTNNB1 and P13K/AKT/mTOR pathways [56].