Ali and colleagues [39] proposed a range of natural compounds for various cancers for treatment, such as balcalein, which reduced MEK1, Bad and ERK1/2 in HCC, and Silibinin with sorafenib [28], which reduced phosphorylation of ERK, STAT3, AKT, MAPKp38 [39]. Here, AKT1 is linked to hepatocellular carcinoma.