As far as the Ψ writer DKC1 is concerned, mutations in this gene have been linked with the reduced pseudouridylation of rRNA molecules, and subsequently with the modified translation of several cancer-associated transcripts, such as the vascular endothelial growth factor (VEGF) and the tumor suppressor p53 mRNAs [179,180,181]. The gene discussed is VEGFA; the disease is cancer.