RARA and acute myeloid leukemia: On the other hand, in AML, the upregulated m6A eraser FTO contributes to the bypassing of growth suppressors by demethylating; this reduces the stability and negatively regulates the retinoic acid receptor alpha (RARA), the ankyrin repeat and SOCS box-containing 2 (ASB2) mRNAs, hampering cell differentiation and promoting leukemogenesis [173].