In hospitalized COVID-19 patients, stress hyperglycemia is associated with worse clinical outcomes and is independently related to levels of cytokines that might impair glucose homeostasis; patients with more severe stress hyperglycemia (stress hyperglycemia ratio > 1.14) have higher levels of Interleuin-10 (IL-10) and CXC motif ligand 10 (CXCL10), a higher IL-10/TNF-α ratio, and have been independently associated with severe stress hyperglycemia [122]. This evidence concerns the gene IL10 and Hyperglycemia.