The results of a study by Krock et al. [86] point to a role for IL-8 in low back pain, demonstrating an increase in: (a) cerebrospinal fluid in patients with low back pain compared to pain-free subjects with and without IDD; (b) in IDD obtained from patients with low back pain compared to a control group without IDD. The gene discussed is CXCL8; the disease is intervertebral disk degenerative disorder.