Dietary supplementation of choline in the amyloid precursor protein/presenilin1 (APP/PS1) mouse model of AD improved spatial memory in the Morris water maze and reduced the processing of APP to amyloid beta peptides with a reduction in microglia activity, which is known to play a role in neuroinflammation, seen in AD, suggesting the potential benefits of diets rich with choline on brain function [148]. The gene discussed is APP; the disease is Alzheimer disease.