PNPLA3 and fatty liver disease: Hepatic fat content variability was also explained for 8.7% by metabolic factors and for 16.1% by inherited variations in overweight children with NAFLD, and this result was confirmed in 2042 pediatric patients in whom the combination of body mass index (BMI), insulin levels, and PNPLA3 and TM6SF2 genetic variants in a PRS seems to be more trustworthy for predicting fatty liver compared to the method based only on BMI and insulin [39,40].