Furthermore, NAFLD exhibits a strong heritable component and polymorphisms in the Patatin-like Phospholipase Domain-containing 3 (PNPLA3), Membrane Bound O-acyltransferase Domain-containing 7 (MBOAT7), and Transmembrane 6 Superfamily Member 2 (TM6SF2) genes, which lead to hepatic fat accumulation and represent the most robust genetic modifiers known to affect NAFLD susceptibility [4,5,6]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.