Some of the contraptions employed by tumor cells to evade immunity checkpoints include the downmodulation and disabling of antigen presentation, the development of immunologic barriers, the downregulation of tumor suppressor genes (i.e., p53, PTEN), hindrance of the programmed cell death pathway (PD-1/PD-L1), T cell tolerance/co-inhibition/dysfunction leading to immune exhaustion and consequently allowing the unbridled division and growth of neoplasms. The gene discussed is CD274; the disease is neoplasm.