The interaction between SARS-CoV-2 and colon cancer cells was hypothesized to happen trough a previously described mechanism that, most likely, guides SARS-CoV-2 infectivity pleiotropism, consisting of an interaction between the S1 protein with the transmembrane receptor neuropilin-1 (NRP-1). Here, PSMD1 is linked to malignant colon neoplasm.