Moreover, in mice models, PCSK9 inhibition improved vascular inflammation and reduced the infiltration of immune cells in the plaque [18]; immunization against PCSK9 increased Th2 lymphocytes and interleukin (IL)—4 levels [19], and it has been suggested that iPCSK9 could suppress the chronic inflammatory state in atherosclerosis [20]. The gene discussed is PCSK9; the disease is atherosclerosis.