TNF and metabolic dysfunction-associated steatohepatitis: Indeed, both TNFα and IL-6 expression were downregulated in an MPO-deficient NASH-murine model, and this anti-inflammatory response was accompanied by a decrease in both neutrophil and lymphocyte hepatic infiltration, as well as by an improvement in NASH-related features, such as liver cholesterol content and the degree of fibrosis [60].