LPS-activated Kupffer cells, via the Myeloid differentiation primary response 88 (MyD88)-dependent signaling pathway, produce proinflammatory cytokines (IL-18, IL-1β, and IL-12) that amplify the cytotoxic activity of NK and CD8+ T cells, and hepatic TNFα and ROS formation, together with insulin resistance. This evidence concerns the gene MYD88 and Insulin resistance.