In turn, according to their physiological functions, T-lymphocytes are divided into different subtypes: cytotoxic T-lymphocytes (Tc or CD8+ cells) and different subsets of T-helper cells (Th or CD4+ cells), including Th1, Th2, Th17 and T regulatory lymphocytes (Treg), which seem to be involved in the pathogenesis of NAFLD [32]. The gene discussed is CD4; the disease is metabolic dysfunction-associated steatotic liver disease.