The activation of these receptors triggers the activation of several signaling pathways (NF-kB, Mitogen-Activated Protein Kinases (MAPK) and caspase-8), leading to systemic inflammation and an acute phase reaction that stimulates hepatocytes to generate the neutrophil-related chemokines IL-8/CXCL8 and growth-regulated protein-α (GROα/CXCL1), thereby promoting the progression of NAFLD [18,113]. Here, CXCL1 is linked to metabolic dysfunction-associated steatotic liver disease.