NR3C1 and Adrenal insufficiency: In summary, OVX or ovarian insufficiency, promoted the fat accumulation and AT expansion, and caused concomitant hyperglycemia by mainly potentiating the Pparg signaling in both VAT and SAT; in contrast, ADX or adrenal insufficiency, universally suppressed the cell proliferation and thus caused lipoatrophy, likely by activating the Nr3c1 signaling in both VAT and SAT.