Sex hormones, e.g., 17β-estradiol [14,15] and follicle-stimulating hormone (FSH) [16,17,18], and adrenal gland-derived factors, e.g., glucocorticoids [11,13], are all evidenced to play pivotal roles in orchestrating AT remodeling as well as the resultant metabolic syndromes in females. The gene discussed is BRD2; the disease is metabolic syndrome.