PER2 and metabolic disease: Through an overlapping analysis of these DEGs centered on Nr3c1 with previously published NR3C1 ChIP-seq data in murine 3T3-L1 cells [32], Fkbp5, Per2, Adrb2, Angptl4, Mc2r, Dusp1, Tle1 and Fosl2 were identified to be Nr3c1 target genes, revealing that these genes may play essential roles in mediating ADX-induced AT aberrant remodeling, as well as the resultant metabolic disorders.