IRS1 and Insulin resistance: Notably, the genes involved in adipogenesis and/or lipogenesis (e.g., Lpin1, Klf15, Vldlr, Per2 and Fabp5) were significantly upregulated, whereas the genes involved in the insulin response (Irs1, Egr2, Agt and Myc) were all significantly downregulated by OVX, in both VAT and SAT, implicating OVX induced the AT expansion and associated insulin resistance through the potentiating Pparg signaling.