The l-CaD expression pattern observed in our study is consistent with a previous study of locally advanced, non-metastatic colorectal cancers treated with neoadjuvant chemoradiotherapy including 5-FU, which showed that CALD1 was among the top genes overexpressed in non-responders [38], most likely via the evasion of apoptosis, as previously shown [17]. Here, CAD is linked to colorectal cancer.