Additionally, prostaglandin-endoperoxide synthase 1 (PTGS1/COX1), prostaglandin-endoperoxide synthase 2 (PTGS2/COX2), and prostaglandin E2 (PGE2) have been reported to be elevated in CJD [329,330], supporting the involvement of inflammation. Here, PTGS1 is linked to Creutzfeldt Jacob disease.