CYP8B1 and intrahepatic cholestasis: Polymorphic variants of CYLD, GC, MBL2, and ZNF572 genes have been collectively associated with the risk of preterm birth or recurrent late pregnancy loss [68,69,70,71,72], while dysregulated expression of CYP8B1 may be responsible for pregnancy intrahepatic cholestasis in mice [73].