NLRP3 and ischemic stroke: Removal of superoxide-generating oxidase 2 (NOX2) has been shown to reduce NLRP3 expression in a traumatic brain injury model and disrupt the NLRP3-TXNIP interaction in the cerebral cortex of mice after ischemic stroke, suggesting a tissue-specific role for cytosolic ROS in activating the NLRP3 inflammasome [56].