A study conducted on rats showed that the combination of quercetin supplementation and physical training exerts a strong anti-cancer and antidepressant effect by suppressing inflammation and regulating the brain-derived neurotrophic factor (BDNF) axis—tyrosine kinase β receptor (TrKβ)—β-catenin in the prefrontal cortex [186]. Here, NTRK2 is linked to cancer.