MR activation can also activate the mammalian target of the rapamycin/ribosomal protein S6 kinase beta-1 (mTOR/S6K1) signaling pathway, which induces vascular insulin resistance via increased serine phosphorylation insulin receptor substrate 1 (IRS1), leading to reduced translocation of glucose transporter 4 (GLUT4) to the cell membrane and glucose uptake [247]. This evidence concerns the gene IRS1 and Insulin resistance.